One of the things that was always a quirk was missing that live, in the room vibe that a Cab gives. The Axe is a full rig, mixed entirely inside so it's the final mic'd sound. So can sound polished and with some FRFR systems it just sounds different than the cabs live in the room. I found that the Mission Eng Gimini 2 remedied that for me. It's loud as hell, 2x12 speakers, the same size as a 2x12 cab, full stereo. In the Axe, if I remove the mic'd part and use no mic's, it brings back that live, in the room cab feel.
I'm sure most of these FRFR systems mentioned here can do the same. But just wanted to point out that by removing the mic'd up section in the Axe and with a beefy FRFR speaker system, it can get that live, raw, in the room feel.