I know I will get raked over the coals here by many but, other than the Few Gilbert ,Petrucci ,Malmsteen .I really do not care for the sound of single coil pickups and high gain.
The slow sustaining lead lines in a ballad and in a few places works great but to me anything fast becomes a blur of mush . Add to the fact the added quality of 60 c hum they just don't work for me.
Any othesr find they just do not dig the single coil high gain combination . I think I just noticed recently when watching demos on you tube and so many people love to use single coil guitars and I am like Yuck
it only becomes mush if you cake all that gain which can make humbuckers sound worse IMO. the trick is getting them to sing with your hands and approach and a good amplifier thats not full of preamp tubes.
some of the best leads ever recording were on single coils, but then again thats when there was a pletora of amps out there with high gain. a pedal and amp is all u needed...or need IMO.