I noticed my 100w 6L6 Stealth getting a ground type of hum in the loop as well. I hardly ever use my loop and I don't recall it doing it previously, but it's been there the past few months. I tried swapping the power tubes and all the preamp tubes one-by-one and it's still there. With a cable in between it doesn't hum, but when I put a pedal in-between it does. I've tried different pedals and get the same result. I've also tried the same pedals and cables with other amps and have no hum. I have all good cables - Colossal, Mogami, & Canare.
I haven't gone too crazy trying to track it down, but next I'm going to try a battery in those pedals rather than a power supply (I use a Voodoo Pedal Power Plus 2) and see if that makes a difference. I'm also going to try cranking up the volume to see if that has any impact on the voice like mentioned above.
FondledDuck, do you notice any other odd noises? I have this ever so slight hum in the background on the green and blue channels. It has a ground hum type of sound, but it's very low in volume. It's something that wasn't there before, but since I typically live on the red channel I couldn't tell you when it started. It increase is volume as the volume goes up. I've wondered if it's related to the louder hum I get when I engage the loop w/a pedal.