I've got 2 heads & 3 combos, used standalone or into cabinets, plus 7 guitars that get played pretty frequently (i won't count the other half dozen that mainly collect dust) and I switch between them constantly. There's only couple of guitar/amp combos within that collection that I'm not crazy about, any other configuration, I can start noodling and get pretty excited about the sound/feel easily enough.
I should probably sell some crap at some point, a few pieces kind of live at our band rehearsal spot, but I've still got way too much to actually justify having all of it.