I personally think Les Pauls do great with EMG's and Fishman Moderns. It depends on the style of music you want to play. I certainly wouldn't use them for 80's and 90's alternative, but I don't think Les Pauls don't work with high output pickups. Plenty of tight, focused, clear high output pickups out there.
A Les Paul with a 500T is fantastic, or a 498T for more versatility, I guess.
Don't get me wrong. I dig PAF types in Les Pauls too. But lots of great sounds have been achieved with Les Pauls and high output pickups. I mean... Doug Aldrich isn't exactly playing Death Metal and his pickup is hot and kinda dark. And it works!
Adam Jones!
JMO.