Playing at home through a 412, I tend to have the bass/resonance turned up most of the way. An EQ in the loop will fix any shortcomings. At louder volumes it fills out better. Playing with a 2x12 and you will definitely want that EQ in the loop.
Also, this comes stock with 6l6/KT88. 4x6L6 would probably increase the bass, but I haven't found it to be an issue with a 4x12. I'd also like to hear more opinions on it, but it's a fairly rare amp.