The fit of the neck will make the most difference, then the mass. Quartersawn (all other things being equal, which is never the case) is more stable. How many of you played baseball back in the wooden bat days? You never held the bat to hit it flat, always into the grain (quarter). Why? Because you would break the bat FAR more often otherwise. This is the same principle behind knives and swords being folded over and over and having a "grain". Or laminated wood products in building materials. It is simple physics. Now as to the tone, quarter oriented wood will have a quicker response (sometimes sound or feel SLIGHTLY stiffer which can be perceived as brightness) and flatsawn will have a slightly slower or squishy response. SLIGHTLY. But again, the fit of the neck to the body makes far more difference.