I used to be all about using vintage high gain all the time, but the last few years I've been using modern more. The key for me is using a Recto 4x12. I've spent hours trying to dial the amp in with other cabs/speakers and generally hated the results, yet with a Recto cab it just all falls into place and sounds so good doing it.
Orange/Clean
V - 9:00, P - 11:00, B - 1:00, M - 8:00, T - 11:30, G - 10:00
Red/Modern
V - 10:00, P - 9:15, B - 1:00, M - 10:30, T - 1:00, G - 12:00
Bold/silicone/FX loop bypassed.
Mine is one of the older, brighter ones. On a later Recto I'd have to run the (Modern mode) bass down around 10:00 and the presence up around 1:00 to get the same sort of sound.