Big MCP fan here.
I have them in a bunch of different guitars, including a couple Afwayu's.
My take on the Afwayu is that it's definately a big and punchy pickup. I have one in the bridge of an SG and it's superb.
But......I have 3 Les Pauls, but only kept an Afwayu in one of them. The bottom end was too much in the other 2. It wasn't that it wasn't tight per se, but just too much vs the other frequencies if you know what I mean.
The Les Paul that still has the Afwayu is the brightest one for sure. Non chambered, and has an extra thick maple top when you look at the inside of the bridge pu route.
The other 2 Paul's have 2nd degree Black Belts and Detroiter's. The 2nd degree BB's are more PAF-ish and the Detroiter's are a little hotter with more snarl, but might not be hot enough, depending on what your looking for.
Haven't tried any other MCP's yet cause I'm kind of addicted to the 2nd degree BB's, but I do have a set of T-Wrecks on order
Not sure what type of tones your going for, but I mostly use the 2 Afwayu loaded guitars with my EVH stealth, Fortin Cali Mod 800, and Bogner Twin Jet when I'm going for really heavy type tones. The Afwayu loaded SG also sounds really good with a rather bright 50watt plexi clone I built.
If your buying new, email Wade and ask him what he thinks. His recommendations are usually spot on.
If your buying used, I say go for it and try the Afwayu.
Especialy if you have a brighter Les Paul. If it doesn't work out, you can always flip it for what you paid for it.
Hope that helps, and good luck with your search!!