Figure out if you want to do the capture/profile thing or just dial shit in like you would an amp.
If I had to pick one to rely on for regular use, it definitely wouldn't be the capture route unless I were intending on capturing my own gear. Relying on other people to provide your ideal tone isn't exactly efficient. That said, a lot of them sound great and if you're not picky, might be more efficient than dialing something in on your own.
Despite everything to come out in the last 7 years, my Fractal stuff isn't going anywhere.