Below is from the Mark V owner's manual
Two 4 Ohm and two 8 Ohm jacks are provided for speaker interfacing. The MARK V is not very sensitive to speaker mismatches and will not be damaged by them, except that very low ohmage loads will cause the power tubes to wear faster. A single twelve-inch 8 Ohm speaker should generally be connected to an 8 Ohm output. When using two 8 Ohm speakers, connect them both to the 4 Ohm outputs provided (because the total load is 4 Ohms in that case.) Check out the information further back in this manual regarding speaker impedance and possible speaker hook-up schemes.
4x12 cabinets may be 4, 8 or 16 Ohms. If you are not sure of the impedance of your cabinet, you may need to remove the Rear Panel in order to verify the impedance rating of the individual speaker or speakers. MESA 4x12 and 4x10 cabinets come standard wired to 8 Ohms, and are wired in series-parallel. Some Non-MESA 4x12 cabinets are wired 16 Ohms using four 16 Ohm speakers. By wiring all four speakers in parallel, you can reduce the cabinet to an impedance load of 4 Ohms (assuming the speakers are 16 Ohms each.) No matter how unusual your speaker setup, it is always possible to get good performance
Wiring up speakers to provide the most effective load and making sure that all of them are in phase will help in creating the best sound possible. This is not too difficult, as long as you understand a few things about loading and how to connect your speakers to provide an optimal resistive load.
MESA/Boogie amplifiers can handle 4 and 8 ohms effectively. Never run below 4 ohms in a tube amplifier unless you are absolutely certain that the system can handle it properly; this can cause damage to the Output transformer. A few amplifiers can handle 2 ohms effectively without damaging them ( for example the MESA’S Bass 400+ ). You can always have a higher resistance ( 16 ohms, for example ) without damaging results, but too low of a resistance will likely cause problems.
MIS-MATCHING: When running a higher resistance ( for example: 8 ohm output into 16 ohm cabinet ), a slightly different feel and response will be eminent. A slight mismatch can provide a darker smoother tone with a little less output and attack. This response is a result of the amplifier running a bit cooler. Sometimes when using more than one cabinet a mismatch will be the only option.