Fulltone Clyde Deluxe user here... Those guys at Fulltone take this 'tone' and 'bypass' and 'perfection' thing very, very seriously. Before choosing, I was given the options of "the best in the business" - Budda, RMC, Area 51, etc etc etc. I test drove a few of 'em and for my tastes, really dug the Clyde Deluxe.
To this day, no issues. I've had it in the chain directly as well as looped, and it's never made a difference when bypassed - at least to my ears. And I will say that they're all awesome wahs when you get up to that level of quality and tone, YMMV.