Hi Mark
Having sound by connecting the guitar (via pedal) to Loop Return shows that 6V6 tubes , V3(12AX7,Phase Inverter) and at least half V2 ( 12AX7 loop reciever) works.
And if one half of V2 works, then the other half of V2 probably also works.
Have you tested to connect a guitar cable between Loop send & return.
(It could be simple fault in the send/return connectors)
But if that doesnt work and you have changed all 12AX7 tubes, then I would guess that one of transistors G2(2N5485) and G1(IRF820) or both are broken.
These two transistor are connected in a Cascode configuration that is the first signal gain stage in the Pre-Amp.
/Kalle