i use straight pedals into
a hiwatt custom 100 .. the thing won't break up without attenuation =0
i tried a load of different pedals, at one point i was using two ODs together which did sound great for certain lead parts, but there was always a little something missing, the tracking/amp like character is hard to get out of some pedals running chips at 9v
took the hiwatt to the local music store, and tried
a blackstar ht dual ... sold me on the spot
i took a step further and had it modded by a german amp tech/modder
in my experience it is doable, i would agree amp dirt is most likely better, but i'm still yet to find an amp that offers me not only the dirt but the versatility and sounds i get out of my pedalboard , usually a great dirt channel won't have the best clean etc.. unless you're paying big dollar
in this case i have a killer clean , and colour it with pedals,
the biggest advantage is i see my whole effects chain at my feet, and no playing around with effects loops/rack units/midi controllers, or having extra long cables running from the amp to the front just for some delay/reverb as well as having boosts and what not in front, it's all in front of me
here's a pic of what i use
the BB preamp is being used as a clean boost, i would get an EP booster, but i like the flexibility of the BB as i don't have that much pedalboard room, the noah's ark is just a loop switcher
i guess i should do some samples of it at some stage probably easier