I use my 50w 5150III with both an EVH 4x12 and a Splawn 4x12 that has an X of V30s and H30s (I run both cabs at the same time) and it's a killer combo between both cabs. The V30 H30 combo alone is actually real good with the III IMO. I tend to find myself standing in front of that cab more than the EVH. It's tighter, more aggressive, a bit brighter (in a good way) and just makes the amp sound a bit meaner I guess you could say.
I didn't like the III with all V30s at all, tried that and it was horrible (yet the original 5150 worked well with all V30s). Adding the H30s brought in some needed tightening, brightening and calmed down the mid heaviness of the two V30s left. The V30 H30 X works well since the speakers voices sort of fill in the blanks of the other one making it a more even sound instead of too bright, too dark or too mid heavy etc. I'm no V30 hater either, they just don't work as well as other options with the III IMO.
Come to think of it I haven't found an amp yet that didn't work well with the V30 H30 X pattern.