My BE100 Hi gain settings:
HBE Channel, switch it off for crunch type tones(yeah still heavy too lol) but it's a perfect balance
Presence just under 6
Bass Cranked all the way
Mids where 3 would be
Treble just under 6
Gain Cranked
Voice switch ON
C45 On
Max tone for days....
Cab= Suhr 4x12 when they were 60's marshall style with dovetails, blue frame scumback m75s, 25 watters