I've never had a 2204 that was lacking in the bass dept. 6550s, EL34s, didn't matter. Preamp dialed to the sweet spot, 7.5-9, always had enough low end for me. I have 2 2204s at the moment. Both have plenty of low end, more than the Mesa .50 Caliber Plus and EVH Stealth 50, unless I dial that depth knob up.
Tho, I've never liked a huge bass sound from my guitar amps. I prefer bright n tight, with healthy mids.
I used a Catalinbread Echorec in front of my JMP 2204 to thicken up the tone.