I have a Painkiller set in my 7-String (Mahogany/Maple/Rosewood) and the Aftermath set in my Edwards Sykes Les Paul (Mahogany/Maple/Ebony).
Both these guitars have a very warm and punchy tonal character, so the bright middy and cutting nature of those pickups makes them a good match.
I wouldn't use either the Painkiller or Aftermath set in a brighter sounding guitar though.
The
Painkiller Bridge has a very punchy and tight lowend. It has a very percussive attack.
And the mids have a very menacing grind. It's a very forward sounding pickup.
The
Painkiller Neck has a very fluid tone under high-gain. It's one of my fave neck pickups for lead playing.
For clean tones the neck splits well, but cleans get even better with both pickups engaged and split.
Very lush and piano-like.
My song below demos the trademark tonal quality of the Painkiller set.
It was recorded entirely with my Painkiller-loaded 7 String guitar.
All high-gain rhythms, leads and all clean tones. All Painkillers:
http://tonefinder.com/index.php?section=id&value=4336
The very middy and cutting tonal character of the Painkiller bridge can get tiring when practicing alone.
But in a full band mix, the Painkiller comes into its own.
And I think that's why the Painkiller has such a polarising opinion base.
It must be played in a mix to fully appreciate what it brings to the table.
The Aftermath bridge is a slightly less-harsh version of the Painkiller IMO.
Less spiky in the highs, and overall a more rounded tone with less sizzle than the Painkiller.
But the lows and mids are equally tight and grindy.
Hope this helps.