Yes. However, there is a quite a bit of confusion on the web on what is series/parallel and what is parallel/series. For example.....google image "series/parallel 4x12" and you will see both variations.
Here is what I found with multiple heads using the same cab and speakers. I'll use different terms for clarification sake:
Speaker pairs wired in series/then paralleled at jack:
More lower mids, a touch more sag, slightly quieter
Speaker pairs wired parallel/then serial at jack (uses one more wire

Brighter, tighter, edgier, and slightly louder
I prefer the former.......especially with Marshally circuits.
I've experimented many times and the difference is not subtle. It's pretty obvious to my ears.