I have Phillips 7581A tubes in my Bruno amp and Tony biased it at 36ma where it should be around 50ma. He siliconed it in that position, so it all comes down to taste as long as it's safe. And it sounds amazing. Amp whiz Bruce Zinky says(regarding his Mofo). "Best done by ear. Set the voltage at pin 5 of the power tubes to about -50 volts or so. Now, set the amp to a low volume clean tone. Play a clean chord, let it sustain, and adjust the bias voltage numerically higher than -51 Volts. The trick is to get the voltage as negative as possible before the sustain goes away and the sound suffers. Raising the voltage above -50 (numerically lower) will increase the power amp gain, but it will lower the maximum power and reduce tube life. Getting the voltage as negative as possible without reducing sustain will give you maximum power, headroom and dynamic response. Of course, if you never use the amp anywhere near full volume , you might like the numerically low "Hot" biasing sound at the volumes you play."