haven't played live in many years, but my computer rig, running Windows 11 Pro, is very stable. I have several Neural DSP plugins, and others for guitar, but my main plugin is PolyChromeDSP McRocklin Suite, I got it as soon as it was launched, $99 US, it's been lower on sale since then, several updates always with new features. It's very stable, and covers a lot of sounds though the focus is on modern tones. I also have their Nunchuck plugin which is based around a modified JCM-800, great for classic tones.
I use BlueCat Audio's PatchWork to organize patches that use different plugins; they have utilities for gain, noise gate, level, etc. so I can mix and match presets using different plugins, and adjust the gain/noise between them in PatchWork without having to go into each plugin.
Next, I organize my PatchWork patches into map sets for my KMI SoftStep2 MIDI controller; whenever I start the rig, or load a new MIDI map set into the SoftStep2, I load each patch once; future patch switching latency is non-existent.