My playing daze are long behind me - and LONG pre-date the advent of modelers. I spent a few years in a band that was booked 3-4 nights a week. Most clubs were Thurs-Sat and a few of the bigger clubs were Wed-Sat. We took off the weekend after New Years and the weekend after 4th of July. Back then, I had a pair of Mesa Mark IIIs and a Mesa Slant 4x12. I only used one amp, but had the second set up behind the cab so I could swap them out in 60 seconds if my main box of glass went down - which never happened. I had no pedals on the floor - just the Mesa footswitch. All of the effects were at the board - our sound man put chorus on my cleans and delay on my leads. Back in the day, it worked and it worked great.
If I had the chance to play 3-4 nights a week again today, I would be hard pressed not to opt for a modeler just for the rock solid predictability of giving front of house the exact same feed every night for every show. I have two close friends who do play out regularly, and they use Fractals for that very reason. Both guys have very different styles and sounds, but both guys sound absolutely killer at every show. I can’t speak to the feel or dynamics of the Fractal as compared to the real deal - but I would probably force myself to get used to it just because the Modeler is SO easy to load in and out, set up and tear down, and again - the consistency back at the board night after night.