I end up lo/hi passing the guitars pretty much every time. I mix as I track so the later in the tracking it is, the less EQ I'll need but I still shy away from dialing things in too 'mix ready' because until I'm just focused on the mix I really don't know what it'll require and that can ultimately make the 'mix ready' stuff sound like shit. I have this preset I made for SSLChannel in Logic, it's my starting point for pretty much every guitar track; at most it's several dB of 1.5K, maybe something around 1K, nothing in the low mids and the usual hacking of 80hz and lower if the hi pass isn't doing it.
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Whether it's an amp/load box or my AxeFX, I try to get the sounds coming out of the monitors to sound as close as an amp sitting right next to me would sound, it's the main way I play at home and it wouldn't be any fun at all to play with neutered tones. Once I got these Yamaha HS8's and got some bass happening without a sub it opened the door for getting things much closer to how it sounds playing an amp in a room. I'd much, much rather play with it feeling as natural as can be and have to hack everything under 80hz off then cut the balls off first and wonder how it'll turn out in the end.
Once a song's well into the mix and I decide to add some guitars, if i hear something standing out as I'm recording it I'll address it before tracking, like sometimes the low end is way too much for tight, palm muted chugging stuff once the bass is already mixed, so to get my tracking tighter I'll hack it off on the amp before it's tracked.