The key to this set-up is that when your effects are not being used, they will be out of the signal and will have minimal effect on your sound.
I’ll to explain the logic behind the way it’s set-up.
The Axess FX1 controls Amp channel switching, Floor effects (GR-X4) & Rack effects via MIDI.
The Axess GX-R4 controls the floor effects (on/off) & also acts as a buffer and true bypass for all the floor effects.
All floor effects are plugged into the Axess GX-R4 for true bypass and buffer (when any of my floor effects are engaged a good buffer will help to keep the signal clean with minimal tone suck)
MXR EVH Phase 90 or Phase 90 script into Loop 1.
MXR Flanger (Will never leave my board) into Loop 2.
Fulltone Deja Vibe into Loop 3.