Hi Ed and Ron, I will have a fairly complex rig. But for starters I try and add a piece at a time. That way I can isolate problems much easier. The problem I have is this:
I started with just my SLO and Surf Box together. They worked great both with the Surf Box in front of, and in the loop of, the SLO. Because I will add a second and a third amp to the rig soon, I need to have the Surf Box in a looper so that any of the 3 amps can be run with it.
So, next step was to try and run the Surf Box and SLO with the RG16. Didn't matter how I ran it, and I used 2 different iso boxes (separately and at the same time in every configuration I could think of), just couldn't keep it from humming very loudly. Tried different cables, loop channels, and ground lifts - but not the ground on the RG. Didn't know it had one.
I am using a power regulator and a conditioner as well.
I will keep playing with it. Been gigging a lot so haven't had time to mess around with it. Cool thing about that is I have been playing without fx and it has taught me a lot. When I add them back in it will be much more judiciously. Also, makes me appreciate the AXE FX that much more. All in one, no ground issues.