Not sure about the Rev 2, but at least on the first one, I find the amp really gets more cutting, tight and better balanced with the channel volume up really high and lower the global volume to compensate. Lowering a lot the presence and mids helps remove bloat or congestion, and treble up high gives you the needed teeth/bite. These are all opposite of how I would dial in knobs on most other amps, but on the Uber it just seems to work well