Hey there,
My guess is that he's using one of the Michael Sweet presets, which is a very particular sound MS likes: cocked wah, almost Rockman without the chorus sound. I'm certainly not a fan (none of my sounds are anything like that). Try any of the other presets other than the MS presets and you might have a good starting point.
Make sure as well, since he's driving a real cabinet, to have the speaker simulators turned OFF in either the globals settings or in whatever patch he's using.
Barring those two options to start, grab the unit yourself and tweak it!
Good luck!