Pretty much like running a traditional EP3 echoplex with the echo bypassed, you may like how it enhances your tone, I like them, I've have two of them the Clinch and Chase tone EP-3 pedals and I love them both. I don't see either making any Friedman sound bad, it would come down to whether you like the nuances it applies to the tone itself. Think Page EVH, you definitely hear and feel a difference for sure when they are turned on.
In this clip into a 69 SL I start stright into the amp then turn on the Clinch EP3 PRE for the Zepplin riffs then I also click on a GE7 EQ for the EVH riffs.