I never considered a 335 because of their design, but happened to play a 60’s 335 at guitar center and thought “this thing rocks” - bought one and am wondering what to attribute the tone differences from a Les Paul to. I’m sure it’s a combination of body design and pickups. But I love how it’s different enough from a LP to be worth owning but close enough you do t have to swap amp settings etc.
I have Throbak SLE 101 in my LP, and while I think I love the T Types, they don’t have the smoother, harmonic jangle in the high end of the Throbaks. But do you even want that in a 335 design? I’m new to these guitars I have no idea. I do know this baby hangs with my 59’ RI Les Paul, has a nice deep growl to it and airy high end. I wish I hadn’t ignored the 335 based on its looks alone for so long

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From what I’ve hear changing pickups is a chore. It’d suck to do a pickup swap and then be unhappy!
Yep, good ES3x5s are magical, this coming from a dedicated metalhead, or at least once upon a time. To me, good LPs are woody sounding, good ES even more so. I think the hollow parts really bring out the acoustic character that contributes to how the string vibrates and therefore translates through the pickup to the amp. Some say that they have a little less sustain, maybe some do, but I've never had a problem with them sustaining. I do think the attack is a little more pronounced, but the whole thing seems to breathe. It's difficult to describe until you've experienced it.
For pickups, if you like the Throbak SLE-101, which is a medium/high output for a PAF, I could recommend the Throbak KZ-115. A little less spendy, I might try the new Gibson T-Top Reissue (not talking about the T-Type). They just released it a week or so ago, and while I haven't tried it, yet, I would expect it would be similar in quality but not in sound to the Custombucker, which are pretty darn good if not quite on the Throbak level.
FYI, there's a trick to changing the pickups in an ES that involves using surgical tubing inserted through the pots' holes and out the F hole, then onto the pot shafts, then pulled through. You can even slide the washer and nut down the tube and attach them before pulling the tube off the pot. I'd recommend putting some really good pots and caps in, although Gibson's stock isn't terrible. I prefer RS Guitarworks, but Throbak sells good prewired harnesses, too.
IMHO when talking about the classic ES3x5 models there are 2 « types » of those, from a sound & feel perspective:
- the ones that sound more like a solid body => those can be very very close to a good equivalent vintage LP;
- the ones that have more of a « hollow body » character.
If yours is more in the 1st camp, you can expect similar results from a pickup swap than what you’d get in a LP. No « bad choices » IMHO, just depends on what you’re looking for.
The 2nd type have a slight different character, but nothing that will make any pickup choice « bad » either; again depends on what you want.
This ^^^ Couldn't have put it better. It seems an exaggeration, but IME, if any pickup sounds good in any guitar, it'll sound good in an ES. Just depends on what you want. Personally, I prefer medium/low output PAF types, better if they're not potted.
IME Les Pauls have a tighter low end with a lot more thundering bass and the 335 has airier high end. If you use too much gain it kind of eliminates the air being noticeable. Member @cobrahead1030 just purchased Heritage versions of both those guitars and A/B'ed them if you pop over to his NGD thread and have a listen. They are more similar than different the more you bump the gain IME.
This ^^^ is a great description of the general differences between an LP and an ES.
Fair warning. If you love LPs, ES are similar enough to make you feel like home and different enough to make you keep them. They have a tendency to multiply, too.
In any case, enjoy the guitar and welcome to the club!