That's what Ed Van Halen did. One volume control. Nothing else. (The exception is the "Van Halen 2" era EVH Limited Edition Bumblebee black and yellow guitar. It had a tone control wired in but it was hidden it the control cavity. I didn't know that until EVH released the expensive version of that guitar. The reason he did that was that the space routed for the bridge pickup was too close to the bridge. Ed said "it's real brittle-bright. I have to do some heavy equalization to get my sound.") I don't know why he didn't have another body made to fix that problem by moving the pickup a little further from the bridge.
My Kramer Superstrat is wired for a single volume control. For me it works very well. You can try different potentiomer values (250K, 300K, 500K, 1 Meg) to tweak the high end. The higher the pot value, the more treble you'll hear. I use a 500K volume pot. It's got a Single/Single/Humbucker pickup layout: Suhr Aldrich bridge, DiMarzio HS-3's in neck and middle. I'm very happy with the sounds I'm able to get with that guitar.
Ask me the time, I'll build you a clock. I blame strong coffee. LOL