I have a 408 and I sold a Tremonti. If you are considering a 408, I suspect you don't play Death Metal.
Here is what you gain... an amazing variety of tonal options in one guitar that you can't really change the pickups in without some doing. This is important to consider.
This guitar sounds like a PRS but shares some tonal characteristics with an ES-335, Les Paul and maybe a tele in some situations. Not a strat so much. It has an amazing rock sound... I mean just the best sound for me ever. Through my Dual Rec high gain with modern voice it can be mean as hell. I LOVE this guitar. I suggest that you take some time and play one.
The Tremonti was awesome... it was a 10 top with birds but it didn't sound like a PRS to me and I wanted it to sounds like a PRS.