I put together live presets for a couple touring bands. Their experience so far has been pleasant. Running the QC on a board up front, 1 output to FOH, another output runs back to a power amp to power a backline of cabs. Pitch shifting your tuning works well only really up to 2 pitches convincingly. A back up is nice, but not totally necessary. I've had Kempers go down more.
You want to leave enough CPU in your preset so that you can run the Global EQ. You can make quick changes to the EQ depending on venue that way on the fly. If you get more time to sound check, just get familiar with how your capture reacts when you tweak the settings a bit.
I had it run with boost pedal captures, a high gain amp, a clean amp and a thicc fuzz pedal capture. It's also nice to have a few boost pedal captures, or at least your boost at various settings to quickly change on the fly at sound check.