The overdrive channel of the Nitro has a 10k mid pot, instead of the typical Marshall-derived 22k or 25k that the Quickrod and most other Marshall-derived high gain amps use. This basically means that on the Nitro your mids are a lot more scooped at comparable settings and even on maximum won't be as effective as on most other amps. This is, however, something very easy for a tech to sort out for you by switching the pot, or even just adding a 10-15k resistor in series with the mid pot, though the latter approach would mean you'd lose the ability to scoop the mids as much as other amps (with the knob on 0 it'd be midrangier than how it currently sounds on 10..).
Also, the depth control is different to most in that it reaches up further into the upper bass/lower mids and will also have more effect at lower settings than most other amps.
With all the above in mind, running the mids at close to full, and keeping the depth off or set very low should give you a voicing more akin to other great sounding, Marshall-inspired amps (including the SLO, 5150 etc). From there you can use the treble and presence more normally, and run the bass anywhere up to full to get the low end extension, if that's what you want.