Gotta read the back the back of the amp. Most amps (like the JVM for instance) have several taps that run something like this:
1 x 16 ohms (single tap)
1 x 8 ohms OR 2 x 16 ohms (two taps)
1 x 4 ohms OR 2 x 8 ohms (two taps)
Also remember that if the cabinets have different power ratings, there is going to be a difference in volume depending on the difference in the power ratings (example: one 100W cabinet w/Greenbacks in parallel with a 300W cabinet with G12T-75's.) Just because the load (ohms) are correct and you won't blow up your OT doesn't mean the volume will be level and it will sound right. You may have to attenuate one of them to get a volume match, unless you have all the same speakers, or the cabinets are configured identically. YMMV.
Hope this helps,