I do love the tighter, aggressive 800 sound. Dont get me wrong. But the plexi thing is like the thicc girl with stuff moving around in all these fun places. Dont diss her by saying "loose and fizzy"! I want that joosy, greazy, chewy wild thing
Ok, but again... the changes you mentioned won't get you those things.
Lower plate voltage = looser and fizzier. Real "Plexi" amps had plate voltages much higher than your average 2204, not lower. Most of the ones I've personally had on my bench were north of 500v, some as high as 530v. Most 2204s are in the mid 450v range. Some as low as 385v, some as high as 480v. Lower voltages = looser and fizzier.
Lower filtering: Sure... many Plexi-era 1959 circuits had lower filtering in some places of the circuit. But the lower you go, the more ghosting you'll get, the more AC ripple you'll get, and the looser the low-end attack will get. But hey... good place to experiment.
NFB: same thing. 100K/4-ohm is the more raunchy of the combinations. Not a bad thing, but combined with lower filtering and lower voltages, it might not yield the results you want.
That said, if you have a surplus of 2204s laying around and you want to mod one, go for it

It's pretty easy to do and if you don't like it, it's easy to go back and/or tweak the circuit to what you do want. But I recommend keeping your B+ no lower than 470v, targeting 350v at the PI node, and no lower than 160v at V1a plate. Filtering is personal preference, but I would consider doing some research to see what the various combinations were for different years. Some had higher filtering at the screen supply and/or main reservoir supply than others, even higher than what you might find in 2204s. PI filtering and preamp filtering were typically lower.
Marshall also made plenty of actual mistakes. Transition-year amps had mistakes for the B+ droppers and preamp filter wiring where they accidentally bypassed one of the stages/droppers, causing two gain stages to share filtering and leave one half of the filter cap unused. This was later corrected. But it's a reason those specific amps had more grit and fizz. I've seen 3 amps in person with this factory error (it's a documented issue).
So yeah... don't be afraid to experiment. Marshall certainly did!