I had a pet Burmese python when I was a teen; started out around 3' long, eating mice; a few years later it was 8' long eating rabbits chickens and small pigs. I donated it to a zoo not long after, it was probably closer to 9' by then, probably around 50 pounds
In my late 20s, a bandmate of mine had a female retic python that was around 16' long, it took three of us to get it out of its pen to feed it.
One thing is when you're feeding them they can sense body heat and movement, and will strike at anything warm that moves once they sense prey. My python bit me several times during feedings; their teeth are curved back, so when they bite both jaws hook into you, and you have to grab the snake's head by the back of the jaws, and unhook one side then the other, while the snake is coiling around you. What's worse is any weight hanging on with the head. Wasn't bad when it was 3-4', but after 6'+...
You have to handle them frequently; they don't know you, but they get used to being handled and tolerate it. If you miss a few days, it's like starting over, and they'll attack you even when you're not feeding them until they get used to being handled again.
My friend's 16' retic weighed about 150 pounds, he was not handling that snake frequently, and feeding time was crazy; the head was nearly a foot long, and half as wide. We'd all go in to open the pen. He'd go in and trap it's head with a pole, then literally sit on the snake's head/neck holding the head down, then we'd go in to lift part of it out of its pen then he'd trap the head with the pole again while we backed away....it would eat a few chickens, small sheep or goats, medium sized pigs. We let go of the meal and he let go of the head, shut the door and watched through a window. Then we had to get it back in the pen after it ate.
Good times. Never again tho'