The Super Distortion is a personal fav with my US Charvel, was pretty much luv at first listen so I never experimented much after that. I also have a Custom Shop which came with a Duncan Custom 5 and I also really like that as it's a nice compliment to the SD, so again, left well enough alone, lol. There are some other great choices with alder Charves obviously - which is part of their appeal, they can be highly 'personalized'...sooo many dudes with Charvels yet you hardly ever see two that look/sound the same.
Here is a WIP vid I'm ssssllllllowly making for a new track of mine using the Charvels + mentioned pickups here (although charveldan slammed the tone door behind him....KILLER tone in that clip!)