I'm going to answer this from a really shreddy angle, like, if you're trying to get better at playing through chord changes I don't know that I'd advocate for this

In the past few years I've learned a couple practice techniques for learning harder things that have enabled me to move on. I got them from Troy Grady's series.
I used to take the exercise and gradually increase the metronome speed as soon as I could play it cleanly at a higher speed. I remember John Petrucci and other guitar icons really emphasizing this! But some things I really couldn't progress any further. I just ended up playing through the same thing over and over and stagnating. So here's what helped:
1) Chunking! This word is used in a lots of ways, and it's also a technique for _learning_ long sequences. In this context, I mean breaking something into short 4-8 note fragments. In this case, there's usually an area of the exercise that's tripping me up, not the whole thing. So I'll take 4-8 notes around there. Maybe it's a weird string change or position shift or something.
2) I don't gradually increase tempo anymore for technique. The technique you use to play slow and to play fast is inevitably different. If you practice an exercise much slower than you want to go, you're likely wasting time, and patterning motions that won't work at high speed. Once I've learned the notes (I will start slow and might gradually increase for that), I go up to the fastest speed that's just at the edge of my ability for that chunk. This is a speed where I'm getting it right sometimes but not all the time, and where I'm not tensing up too much. Then I'll play just that difficult chunk at that tempo, focusing on staying in the groove and staying as relaxed as I can. Then once that's solid, I'll increase the tempo as much as I can to the edge of my ability.
Once I've done that for all the difficult chunks to as fast as I want to get, I'll put it all together.
And more directly to your question, there are some things I'm working on that are long-term endeavors. I'm never going to alternate pick arpeggios as fast as Steve Morse or Andy Wood. But I'll keep returning to that. When I practice that technique, I'm usually taking a 4-8 note sequence that's, say, a chunk from Tumeni Notes or Free Range Chicken, that's particularly difficult for me, and working that at a high tempo. I'm not playing through the whole piece so much. I'm focusing on the parts that are hard for me at tempos that are hard for me.
I also find that if I learn a really hard technique, if I take a few weeks off, I won't have it immediately, but using this motor learning strategy, it'll come back pretty fast. I just go back to those difficult chunks at a fast tempo and it comes back.
Like others are saying, I think the point of practice is to be doing stuff that's on the edge of your ability. Is there a specific exercise you're working on?