Since I am in a similar situation here is what I do... but a little back story to help...
I moved to digital load boxes around 2017, new marriage and life style changes, these allowed me to do what I wanted to do when I wanted to do it without upsetting the misses. It tooks a while to get use to them, but once I did it made everything after a lot more convenient and comfortable. I always liked the idea of MFX units, but struggled with a few namely Helix, to get sounds that I enjoyed...
About 5 years ago I took a job where I travel typically 4 nights a week, I wasnt playing much at all when I started this job and had other hobbies I was into, but I would take a guitar occasionally. During this time, my interface died on me and left my home set up almost unusable, took longer than I care to admit to fix it, but I finally did a little over a year ago. I was getting the playing bug again and getting it pretty hard but I knew carrying amps in a car and hotel room night after night wasnt a great idea. I was using the Helix for a bit and comfortable enough with the sounds I was getting, that I ended up snagging the Pod Go, it made things significantly easier to lug around. I was content, but not thrilled with it... but this time I wanted to actually get better at guitar. So, the Truefire membership, Troy Grady membership, Lick Library membership, all gave me a load of material to sift through but no clear direction.
When I started back this past year I decided to keep a practice journal as well. I was keeping track of what I was working on, setting goals, using it to set my practice routine based on what I wanted and needed to work on. I filled this note book up completely and keep forgetting to buy a new one to continue doing this. It has really helped me hold myself accountable to achieving the goals I have set. For the most part it has been a success, but I still have a few areas I really need to work on and dont dedicate the time I need to in order to do that.
I started taking lessons with @Techdeth this summer, and I am doing things now I was only dreaming of doing when I was younger. I also moved into the fractal gear earlier this year and have really become a fan boy since I started using it, even replacing my pod go with an FM3, and now instead of just having sounds I was ok with, I have sounds that I actually enjoy. But one thing the Line 6 did do for me, it stopped me from obsessing so much over what my rig sounded like, and just get to the playing and practicing.
I have built a small mobile studio so to speak I can set up in a hotel room in just a couple of minutes, and I have yet to receive any complaints about volume at any hotel I am at. Laptop, small interface, IK multimedia iLoud small monitors, FM3 and guitar, everything but the guitar fits in a back pack. I have the EZdrummer and Superior drummer to build drum loops with, guitar pro to play a long and practice with, pro tools to record with when I finally start doing that again. The main thing I am looking for now is people to collaborate with. I would love to get in with some people around my home to play with, but being gone Mon - Fri, im overly cautious about trying to dedicate too much time where I would be gone during the weekends.