In Practice
Our ATR series of hybrid amps the Jupiter, Startrooper and ATR4502 (see also the blog article about these amps), are designed in such a way that they react the same way to speakers as tube amps. Although they operate with mosfets to drive the speaker, their ouput power does not fall back to 50% if the impedance is doubled. This is one of the reasons why our ATR series of hybrid guitar amplifiers sound like real tube amps.
Although their speaker outputs behave similar to tube amps you can safely disconnect the speaker and play them without a speaker or load connected. If you do that you will not damage anything.