So first post, A was the amp and B was the Fractal. Listening back to it, the Fractal sounded weird.
Second set, I redid the Fractal T/M/B and presence/resonance setting and then flipped the order of the clips. A was the Fractal and B was the amp.
The 5150 is the opposite of my experience with the 2204/Fractal Brit 800. While the Brit 800 is gainier and more compressed than the 2204, the real 5150 is gainier and more compressed than the Fractal 6160 model.
For kicks, here's a direct recording of the Fractal with the newer settings. I don't have a way to record my amps direct.
The tone did change quite a bit, but of course an iPhone vs a pro IR of a different cab would do that I guess.