While I doubt I’ll ever give up my Cherry Bomb and I love my Mark III+, I think the Synergy stuff is top notch!
I have a ton of experience with the Randall and Egnater modular stuff, including a lot of the modded modules, I think the Synergy system is a definite step up.
I own the Syn 50 and like it quite a bit bit as the platform. For modules, my three go to’s are the Drect, the Pitbull and the Cali. I have also kept the 6505, VH4 ( somewhat of a surprise because I didn’t get along with any of the real amps that I owned) and the BE DLX. Have owned pretty much all the high gain modules and these fit me best. The IIC was cool too, but I have that ground more than covered with the III+.