I used to be into thicker strings, cause of the way they held tune and that I could beat on them(I'm mostly a rhythm player). Now, I'm using lighter strings, only because I've been trying to get better at lead'ish playing, and 12's and higher were beating up my fingers.
So for anything from E to C I use 10-52, for drop B I use 11-54 and A#/A I use baritone lights like 12-63.
All of my guitars are 24.75" scale.