Anything but a les paul or other guitars that have too strong of a character for me. It's like asking somebody to eat the same dish of food everyday. Even if it's the greatest stake it'll be the same every fucking day.
Probably a fat strat or superstrat with great single coil and 2/4 sounds. 25 to 25 5 scale for sure.
As far as amps go, it's the same. Something that can serve a lot of songs and do that great every time. From clean to crunch to thrash to modern heavy.
Maybe a steavens poundcake, a roadster or a brunetti 059 with the EL84/El34 power section and plexi modes etc...I've yet to find a "better" amp anyway.
One guitar an one amp for life, damn that is restricting!