Sure! I have a Bill Lawrence Swampkaster T. I swapped the bridge to one that's not a wraparound, and cut a pickup ring out of pickguard plastic for the bridge pickup which extends right to the bridge another few mm (to cover up that part of the rout). I wasn't that picky about how the wraparound bridge sounded, but I swap pickups a lot, and removing the bridge every time got on my nerves.
Anyway, slap a neck onto a 2x4 and it's a guitar as long as you line things up. And it's good for metal if you have the right pickups installed.
Most of the "tele twang" comes from how the stock bridge pickup has a metal base (and it connects through the screws to the metal wraparound bridge). Change pickups to one without a metal base (single-coil sized humbucker for instance) and most of that twang is gone. Change the wraparound bridge to a non-wraparound type (and add a plastic pickup ring) and that's pretty much the rest of the twang removed. If it's a particularly bright sounding guitar it'll have some inherent "pop" and/or "twang" left (with the ratio of that being dependent on how dense the woods are), but it won't really sound like a tele at that point. Bright guitars work well for metal anyway.
Oh keep in mind standard tele neck pickups are smaller than strat sized ones. If you plan to swap that as well (to a strat-sized pickup), you might end up having to modify your pickguard (and I guess depending on the exact guitar, the rout might need a bit of expansion although it's probably fine).
