Tried multi channel amps many times….always ended up just using one of the channels for 99% of the tones.
Started off with a '69 Marshall and used it (along with various others) with a few pedals. Hated delay in front and still do except for the Digidelay, some reason it works ok.
Then went to a 5150…used the normal gain input on the Red channel. FX in loop
Then went to a VHT UL…..used Channel 2 toggling the boost, od pedal and gtr volume controls for everything. FX in loop
Then went to a custom Wizard Metal/ MC…..just use the lead channel for everything. FX in loop
Don't play in bands anymore, but most likely if I did, would do the same thing.