To elaborate on my two points while I have a chance to type more detail...
Many of the modules are designed by the actual company/designer who did the actual amp. IIRC Steven Fryette did several of the others non "branded" ones so it's not like you're getting a module designed by some corporate hack. While maybe not sounding the exact same, you're still going to get something as close to the original amp as possible. As long as you think of it like an additional channel or different revision of the actual amp there's a low chance you'll be disappointed.
This is from my personal experience on how the power amp makes a difference in the final tone.
First example is my IICP module. I also have a Mesa Mark III to compare it to.
*Note reference the color chart at the bottom of this post to understand the analogy.
- I tried the IICP through my H&K Tubemeister 36 and it was pretty much ass all around. The EL84's and tiny transformers just were not a good fit to get a good full Mark amp tone. Don't get me wrong, it would work enough to get by, but there's much better options. I tried running it throught a couple other EL84 amps. While better than the Tubemeister it still wasn't a good fit. The shade wasn't even part of the color card.
- Going through my modded Randall RM100 was much better. The big boy tubes brought the big boy tone. Direct comparison to my Mark III, while minor, you could hear a difference. The RM100 colored the overall tone a little. It's like comparing Simply White to Cappuccino White. They're both similar shades, but you can tell a difference.
- Running it through my PS100 Powerstation was different from both the RM100 and the Mark III. The PS100 is a much more neutral power amp so the module did the heavy lifting. It was closer in tone to the Mark III than the RM100 was. Again still White, but a different shade than the original; like Simply White To Alabaster.
- Next was running the IICP through the Mark III. In this scenario the module was 99.5% the sound of the Mark III. The only difference I could tell when paying attention was the IICP was a slight bit smoother sounding the the Mark III. Everything else on the tone and feel was damn near the exact same. In fact when messing around with this setup, I would lose track of which one I was on they were so close. I'd compare it to Simply White and Ivory Keys, but the shades were even closer than that.
- Lastly is running it through my BV300 which is essentially putting the module through an Ampeg SVT power section. This gives me a different sound than anything above. As far as tone goes it still fits into the color card, being close to simply white; however, the 300 watt power section gave it so much more girth than anything else. I've never played a Mark Coliseum, but I could imagine this setup would be a similar experience. It's not a 1:1 comparison to my Mark III or any of the other setups I've tried, but it's by far my favorite.
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I had a similar experience with my Savage and Powerball modules. While I don't own the actual amps for direct comparison, I have played though them to mostly know what they sound like. It wasn't worth it on the puny tubes/amps. The RM100 gave the modules a slightly different color. Nothing bad at all, but enough that you could hear it's influence. The PS100 was closer to what I remember the actual amps sounding like, but it didn't have that typical ENGL feel. Going through my ENGL Inferno & Morse was the best representation of the actual amp. The tone wasn't too far off from the PS100, but now it had the feel of an ENGL amp.
So like I was saying before Synergy is 100% worthy. You just have to understand what you are getting, know what you want to accomplish with it and set expectations accordingly. Personally I got into the Synergy platform because I'd like access to certain tones, but I don't really want to invest the money and space towards the actual amp. I'm fully satisfied with the 97%-99% representation of the actual amp. Then there's the added bonus of running modules through different power sections for a slightly different experiences; like the IICP into the BV300.