I might get the AXE FX one day... but being a VG99 owner and using all modeling, I decided to pick up the Renegade Head and got and empty Tourmaster 2X12 to load a Scumback H75 and a M75 in it.
I'll also going to re-tube the Renegade with a set of SED =C= EL34s and Svetlana 6550s. Then, I'll pic up a few analog pedals and perhaps a few good digitals like the Eventide Timefactor and Modfactor.
This (btw) is all in my studio. I guess (IMHO) having an all digital modeling device that sounds the same day in and day out is like using the same sample pianos, same sample vocal phrases, same sample drums over and over. For live and playing a lot of different music where you needed to change sounds and patches on the fly, the AXE is a plus. But for me, I guess I want something that isn't like everyone else.
Tube amps can vary from day to day, depending on the age of the tubes, electrical current, the temperature of the room, the humidity, mic placement, etc. Even the subtle difference when you change the eq where its like not exactly the same setting every time. I also like something that can be sculpted a bit different and make it "my own" so to speak with different vintage pedals, mics, speakers, etc.
However, I do like blending the best of both worlds. With that said, I also might try the VB-101 or the VM-202 by Two-Notes. That way I would still use my head and my tubes but their cab sims and mics.