Keep in mind that im a caveman that doesnt use use any effects but a wah and noise gate in front. However, when i play out, i run my uber through its cab, the DR through two cabs bookending the uber stack. Then i can switch between the two amps' four channels, and not really affect the "location" of my guitar sound in the live sound of the band. Since its mostly rock and metal rhythm, i dont really miss effects.