Are you set on a tube amp? An Axe-FX II XL would do what you needed, with either a set of FRFR speakers or a power amp into your Vader cab. Just make sure to turn off the speaker sims if you're using a guitar cab. A Kemper would be good too. With either of those platforms, you can play around with 1000s of amp sounds until you find something that works for you. You mentioned Animals as Leaders, who use Axe-FX for all of their amp sounds AFAIK.
If you'd prefer a traditional tube amp, I'd look at a Fryette Pitbull/Sig:X/Deliverance, EVH 5150 III (each model sounds a bit different), Mark V:25, maybe a Friedman if you're into the modern interpretation of the Marshall sound.